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A convenient microwave-assisted synthesis of cinchona alkaloid-derived ligands |
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| Authors: | Hai Bo Wang Ping An Wang Quan Jun Wang Xiao Li Sun Lin Lin Jing |
| Affiliation: | Department of Chemistry, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China |
| Abstract: | An efficient synthesis of cinchona alkaloid-derived ligands based on solvent-free microwave-assisted reaction was described. The coupling of 1,4-dichlorophthalazine or 3,6-dichloropyridazine with quinine, cinchonine or cinchonidine provide bis- or mono-cinchona alkaloid-derived ligands in moderate to good yields (52-89%) within 15 rain under optimum microwave conditions. |
| Keywords: | Cinchona alkaloids Solvent-free microwave synthesis AD reaction |
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