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Stereoselective Total Synthesis of Mangiferaelactone using D‐Mannose as a Chiral Pool |
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| Authors: | Basi V. Subba Reddy Pathuri Sivaramakrishna Reddy Kummari Vijaya Babu Bhemavarapu Phaneendra Reddy Jhillu Singh Yadav |
| Affiliation: | Natural Product Chemistry, CSIR‐Indian Institute of Chemical Technology, Hyderabad‐500 007, India, (fax: +91?40?27160512) |
| Abstract: | A convergent total synthesis of mangiferaelactone has been accomplished in a highly stereoselective manner from readily available D ‐mannose. The following methods like organocatalytic enantioselective epoxidation, ring‐closing metathesis, and Steglich esterification have been employed as key steps, which make this approach more attractive. |
| Keywords: | 10‐Membered macrolides Ring‐closing metathesis MacMillan asymmetric epoxidation |