One‐Pot Four‐Component Synthesis of Thieno[2,3‐d]pyrimidin‐4‐amines via Sequential Gewald/Cyclocondensation Reactions |
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| Authors: | Mehdi Adib Helia Janatian Ghazvini Mehdi Soheilizad Sara Saeedi Mahmood Tajbakhsh Massoud Amanlou |
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| Affiliation: | 1. School of Chemistry, College of Science, University of Tehran, P.?O. Box 14155‐6455, Tehran, Iran (phone/fax: +98‐21‐66495291);2. Department of Organic Chemistry, Faculty of Chemistry, Mazandaran University, Babolsar, Iran;3. Pharmaceutical Sciences Research Center and Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran |
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| Abstract: | A one‐pot four‐component synthesis of thieno[2,3‐d]pyrimidin‐4‐amines via sequential Gewald/cyclocondensation reactions is described. 2‐Aminothiophene‐3‐carbonitriles obtained from the Gewald reaction between cyclic ketones, malononitrile, and sulfur underwent a condensation? cyclization reaction with benzonitriles under solvent‐free conditions to afford the title compounds in excellent yields. |
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| Keywords: | Thieno[2,3‐d]pyrimidin‐4‐amines Gewald/cyclocondensation reactions Multicomponent reactions (MCRs) Solvent‐free synthesis |
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