Phenolic Derivatives from the Root Bark of Oplopanax horridus |
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| Authors: | Wei‐Hua Huang Qing‐Wen Zhang Chong‐Zhi Wang Chun‐Su Yuan Shao‐Ping Li |
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| Institution: | 1. State Key Laboratory for Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR, P.?R. China, (phone: +853‐83974692;2. fax: +853‐28841358);3. Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P.?R. China;4. Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, 5841 South Maryland Avenue, MC 4028, Chicago, IL 60637, USA, (phone: +1‐773‐7021916;5. fax: +1‐773‐8340601) |
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| Abstract: | Four new phenolic derivatives, including two phenylpropanoid glycosides, one benzoate glycoside, and one lignan glycoside, together with one known glyceride, were isolated from the root bark of Oplopanax horridus. The structures of the new compounds were elucidated as 3‐{4‐(6‐O‐acetyl‐β‐D ‐glucopyranosyl)oxy]‐3,5‐dimethoxyphenyl}propanoic acid ( 1 ), (+)‐5,6,7,8‐tetrahydro‐7‐(hydroxymethyl)‐10,11‐dimehoxydibenzoa,c]8]annulen‐6‐yl]methyl β‐D ‐glucopyranoside ( 2 ), (+)‐methyl 4‐6‐O‐{3‐hydroxy‐3‐methyl‐5‐(1‐methylpropyl)oxy]‐5‐oxopentanoyl}‐4‐O‐(β‐D ‐glucopyranosyl)‐β‐D ‐glucopyranosyl)oxy]‐3‐methoxybenzoate ( 3 ), and 2‐methoxy‐4‐(1E)‐3‐methoxy‐3‐oxoprop‐1‐en‐1‐yl]phenyl 6‐O‐{3‐hydroxy‐3‐methyl‐5‐(1‐methylpropyl)oxy]‐5‐oxopentanoyl‐4‐O‐β‐d‐ glucopyranosyl‐β‐d‐ glucopyranoside ( 4 ) on the basis of spectroscopic techniques including NMR and MS analyses. The known compound was identified as glycer‐2‐yl ferulate ( 5 ) by comparing its physical and spectral data with those reported in the literature. |
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| Keywords: | Phenylpropanoids Lignans Oplopanax horridus |
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