Steroidal Alkaloids from Veratrum dahuricum (Turcz.) Loes. f. with Genotoxicity on Brain Cell DNA in Mice |
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| Authors: | Yue Cong Jing Li Qing‐Chun Zhang Jing‐Gong Guo Sha‐Sha Li |
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| Institution: | 1. Institute of Pharmacy, Pharmaceutical College, Henan University, Jinming Road, Kaifeng 475004, P.?R. China (phone/fax: +86‐371‐23880680);2. The Key Laboratory of Plant Stress Biology, Henan University, Jinming Road, Kaifeng 475004, P.?R. China |
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| Abstract: | Two new steroidal alkaloids, 2β‐hydroxyverdine ( 1 ) and tomatillidine 3‐O‐β‐D ‐glucopyranoside ( 2 ), were isolated from the root and rhizome of Veratrum dahuricum (Turcz .) Loes . f., together with four known compounds, i.e., 16‐O‐(2‐methylbutyroyl)germine ( 3 ), veramitaline ( 4 ), jervine ( 5 ), and veratroylzygadenine ( 6 ). Their structures were established by extensive spectroscopic analysis, as well as by comparison with data in literature. Compounds 1 – 6 exhibited genotoxicity on brain cell DNA of the cerebellum and cerebral cortex in mice, evaluated by using single‐cell gel electrophoresis (comet assay). |
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| Keywords: | Veratrum dahuricum Verdine 2β ‐hydroxy‐ Tomatillidine 3‐O‐β ‐D‐glucopyranoside Genotoxicity |
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