Three New Lignan Derivatives from Lindera glauca (Siebold et Zucc.) Blume |
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| Authors: | Won Se Suh Ki Hyun Kim Ho Kyung Kim Sang Un Choi Kang Ro Lee |
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| Affiliation: | 1. Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon 440‐746, Korea, (phone: +82‐31‐2907710;2. fax: +82‐31‐2907730);3. Korea Research Institute of Chemical Technology, Daejeon 305‐600, Korea |
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| Abstract: | Two new aryl‐tetralin lignan glycosides, linderanosides A and B ( 1 and 2 , resp.), and a new dihydrobenzofuran neolignan glycoside, linderanoside C ( 3 ), together with five known lignan derivatives ( 4 – 8 ) were isolated from the trunk of Lindera glauca. The structures of these new compounds were determined through spectroscopic analyses, including extensive 2D‐NMR data and acid hydrolysis. The absolute configurations of the compounds were clarified by circular dichroism (CD) spectroscopic studies. Compounds 1 – 8 were evaluated for their cytotoxicity against A549 (non‐small cell lung adenocarcinoma), SK‐OV‐3 (ovarian cancer cells), A498 (human kidney epithelial cells), and HCT‐15 (colon cancer cells) human tumor cell lines using sulforhodamine B assays in vitro. |
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| Keywords: | Lindera glauca Lignans Linderanosides A and B Cytotoxic activity Sulforhodamine B (SRB) bioassay |
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