Identification of Five New Minor Constituents from the Whole Plant of Amischotolype hispida |
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| Authors: | Chun‐Wei Chang Hsun‐Shuo Chang Ming‐Jen Cheng Chien‐Fang Peng Ih‐Sheng Chen |
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| Institution: | 1. Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, (phone: +886‐7‐3121101 ext. 2191;2. fax: +886‐7‐3210683);3. School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan;4. Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu 300, Taiwan, (phone: +886‐3‐522‐3191 ext. 585);5. Department of Biomedical Laboratory Science and Biotechnology, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan |
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| Abstract: | Bioassay‐guided fractionation of the active AcOEt‐soluble layer from the whole plant of Amischotolype hispida resulted in the isolation of four new compounds, i.e., amisbenzoic acid ( 1 ), one butenolide derivative, amisnolide ( 2 ), one chlorin analog, amisphytin ( 3 ), one lignan, amislignol ( 4 ), and one metabolite isolated for the first time from nature, (?)‐glaberide I ( 5 ), along with 20 known compounds, 6 – 25 . Their structures were elucidated on the basis of UV, IR, 1D‐ and 2D‐NMR (1H,1H‐COSY, DEPT, HSQC, HMBC), as well as HR‐ESI‐MS, analyses. Among these isolates, palmitic acid ( 13 ) showed an antimycobacterial activity with an MIC value of 20.0 μg/ml against Mycobacterium tuberculosis H37Rv. |
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| Keywords: | Amisbenzoic acid Amischotolype hispida Amislignol Amisnolide Amisphytin Glaberide Antimycobacterial activity |
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