Bioactive Trichothecenes Produced by the Myrothecium sp. QB‐1 |
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| Authors: | Ren Ren Chao‐Jun Chen Xian‐Xian Liu Hui‐Ming Ge Ren‐Xiang Tan Rui‐Hua Jiao |
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| Affiliation: | Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P.?R. China, (phone/fax: +86‐25‐83593201) |
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| Abstract: | Three new simple trichothecenes, 15‐acetyltrichoverrol B ( 3 ), 13′‐acetyltrichoverrin B ( 5 ), and 6′‐dehydroxytrichoverrin B ( 6 ), along with five known trichothecenes trichodermadienediol B ( 1 ), trichoverrol B ( 2 ), trichoverrin B ( 4 ), and roridins A ( 7 ) and D ( 8 ), have been isolated from the liquid culture of Myrothecium roridum (strain no. QB‐1). The structures of the new compounds were established by comprehensive analysis of 1D‐ and 2D‐NMR data. All the compounds were evaluated for antifungal activity, only compounds 7 and 8 showed significant antifungal activity against the tested fungi (MIC ranged from 10 to 5 μg/ml). |
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| Keywords: | Myrothecium roridum Trichothecenes Antifungal activity Raphanus sativis |
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