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Synthesis of a Regioisomer of β‐Lapachone and Analogs as Potent Antitumor Agents |
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| Authors: | Qunshan Ding Yan Zhang Zhenhua Shen Chuanjun Song Junbiao Chang |
| Affiliation: | 1. College of Chemistry and Molecular Engineering, Zhengzhou University, 100 Science Avenue, Zhengzhou 450001, P.?R. China;2. Henan Academy of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450052, P.?R. China;3. Henan Key Laboratory for Pharmacology of Liver Diseases, Zhengzhou 450052, P.?R. China |
| Abstract: | A regioisomer of β‐lapachone and two analogs were synthesized and evaluated for their antitumor activities. All three compounds tested were found to exhibit promising activities against PC‐3, HepG2, and Raji cancer cell lines in μM range. |
| Keywords: | β ‐Lapachone Antitumor activity Naphthoquinones |