Diterpene Glycosides from the Dry Fronds of Conyza japonica |
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| Authors: | Jiang Hu Hui Li Xia Mao Xiaodong Shi Zhiming Liu |
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| Institution: | 1. College of Biological Resources and Environmental Science, Qujing Normal University, Sanjiang Avenue, Unicorn District, Qujing 655011, P.?R. China, (phone/fax: +86‐874‐8998627)These two authors contributed equally to this work.;2. College of Physics and Electronic Engineering, Qujing Normal University, Qujing 655011, P.?R. China;3. College of Biological Resources and Environmental Science, Qujing Normal University, Sanjiang Avenue, Unicorn District, Qujing 655011, P.?R. China, (phone/fax: +86‐874‐8998627);4. The First People's Hospital of Qujing, Qujing 655000, P.?R. China |
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| Abstract: | Phytochemical investigation of the 95% EtOH extract of the dry fronds of Conyza japonica (Thunb .) Less. resulted in the isolation of three new labdane diterpene glycosides, (3β,13S)‐13‐O‐α‐L ‐rhamnopyranosyllabda‐8(17),14‐dien‐3‐yl α‐L ‐rhamnopyranoside ( 1 ), (3β,13S)‐13‐O‐α‐L ‐rhamnopyranosyllabda‐8(17),14‐diene‐3‐yl 2‐O‐acetyl‐α‐L ‐rhamnopyranoside ( 2 ), and (3β,13S)‐13‐O‐α‐L ‐rhamnopyranosylabda‐8(17),14‐dien‐3‐yl 6‐O‐acetyl‐β‐D ‐glucopyranosyl‐(1→2)‐α‐L ‐rhamnopyranoside ( 3 ), together with their aglycone, (13S)‐labda‐8(17),14‐diene‐3,13‐diol ( 4 ). Their structures were characterized by spectroscopic analyses and chemical correlations, including 1D‐ and 2D‐NMR, and HR‐ESI‐MS. Furthermore, compounds 1 – 3 appeared to be promising as active agents against the tested pathogen fungi and oral pathogens as they possessed moderate cytotoxic properties. |
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| Keywords: | Conyza japonica Diterpenes Antimicrobial activity Cytotoxic activity |
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