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Facile Synthesis of 5‐Hexyl‐4‐methyl‐γ‐butyrolactone via Nef Reaction as a Key Step |
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| Authors: | Zhi Li Changwei Wang Pengju Feng |
| Institution: | 1. Department of Chemistry, School of Science, Beijing Jiaotong University, Beijing 100044, P.?R. China;2. Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, P.?R. China;3. Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P.?R. China, (phone: +86‐10‐51683627;4. fax: +86‐10‐51683627) |
| Abstract: | A racemic cis/trans mixture of 5‐hexyl‐4‐methyl‐γ‐butyrolactone was easily synthesized from 1‐iodoheptane in four steps with inexpensive and readily available reagents. Our new synthesis method can be potentially employed for mass production of the 4‐methyl‐5‐hexyl‐γ‐butyrolactone as well as other poly‐alkyl substituted γ‐butyrolactones. |
| Keywords: | γ ‐Butyrolactone 5‐hexyl‐4‐methyl‐ Lactones Nef reaction Ozone |