Structure and Absolute Configuration of Aspergilumamide A,a Novel Lumazine Peptide from the Mangrove‐Derived Fungus Aspergillus sp. |
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| Authors: | Cai‐Juan Zheng Lu‐Yong Wu Xiao‐Bao Li Xin‐Ming Song Zhi‐Gang Niu Xiao‐Ping Song Guang‐Ying Chen Chang‐Yun Wang |
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| Institution: | 1. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, P.?R. China, (phone: +86‐898‐65889422;2. fax: +86‐898‐65889422 ext. 571158);3. Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, P.?R. China, (phone: +86‐532‐82031536;4. fax: +86‐532‐82031381 ext. 266003) |
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| Abstract: | A novel lumazine peptide, aspergilumamide A ( 1 ), as well as a known analog penilumamide ( 2 ), were isolated from the mycelia of a marine‐derived fungus Aspergillus sp. (33241), obtained from the mangrove Bruguiera sexangula var. rhynchopetala collected from the South China Sea. The structure of 1 was identified by comprehensive spectroscopic analysis, including 1D‐ and 2D‐NMR, ESI‐MS, and MS/MS experiments. The absolute configuration of 1 was determined by Marfey's method. |
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| Keywords: | Aspergillus Lumazine peptide Marfey's method Cytotoxic activity Antibacterial activity |
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