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Stereoselective Total Synthesis of Stagonolide E |
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| Authors: | Singanaboina Rajaram Udugu Ramulu Seema Aravind Katragadda Suresh?Babu |
| Institution: | 1. Division of Natural Products Chemistry, CSIR‐Indian Institute of Chemical Technology, Hyderabad 500?007, India, (phone: +91‐40‐27191881;2. fax: +91‐40‐27160512) |
| Abstract: | An efficient and highly stereoselective synthesis of stagonolide E ( 1 ) starting from the readily available hexane‐1,6‐diol ( 8 ) was accomplished, employing MacMillan α‐hydroxylation, Horner? Wadsworth? Emmons olefination, (Z)‐selective Still? Gennari olefination, and Yamaguchi lactonization as key steps. |
| Keywords: | Horner Wadsworth Emmons olefination MacMillan α ‐hydroxylation Stagonolide E Yamaguchi lactonization Still Gennari olefination |