New Casbane Diterpenoids from the Hainan Soft Coral Sinularia Species |
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| Authors: | Bin Yang Jingxia Huang Xiuping Lin Shengrong Liao Xuefeng Zhou Juan Liu Junfeng Wang Lishu Wang Yonghong Liu |
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| Affiliation: | 1. CAS Key Laboratory of Tropical Marine Bio‐resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, P.?R. China, (phone/fax: +86‐20‐89023244);2. Zhongshan Ophthalmic Center, Sun Yat‐Sen University, Guangzhou 510060, P.?R. China;3. Jilin Provincial Academy of Chinese Medicine Sciences, Changchun 130021, P.?R. China |
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| Abstract: | Six new casbane diterpenoids, sinularcasbanes G–L ( 1 – 6 , resp.) were isolated from the soft coral Sinularia sp. Their structures were established by extensive spectroscopic analyses, especially 2D‐NMR and HR‐ESI‐MS. The configuration was confirmed by CD analyses and by comparison with data reported in the literature. The compounds were evaluated for cytotoxicity against ten human cancer cell lines (H1975, U937, K562, BGC823, MOLT‐4, MCF‐7, A549, HeLa, HL60, and Huh‐7) and showed no activity. |
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| Keywords: | Sinularia Casbane diterpenoids Cytotoxic activity |
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