Steroidal Alkaloids from Veratrum maackii Regel with Genotoxicity on Brain‐Cell DNA in Mice |
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| Authors: | Yue Cong Hua‐Lan Zhu Qing‐Chun Zhang Lin Li Hai‐Yan Li Xian‐You Wang Jing‐Gong Guo |
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| Institution: | 1. Institute of Pharmacy, Pharmaceutical College, Henan University, Jinming Road, Kaifeng 475004, P.?R. China (phone/fax: +86‐371‐23880680);2. The Key Laboratory of Plant Stress Biology, Henan University, Jinming Road, Kaifeng 475004, P.?R. China (phone/fax: +86‐371‐22857224) |
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| Abstract: | Two new steroidal alkaloids, 23‐methoxycyclopamine 3‐O‐β‐D ‐glucopyranoside ( 1 ) and isoecliptalbine ( 2 ), were isolated from the root and rhizoma of Veratrum maackii Regel , together with five known compounds, i.e., verussurine ( 3 ), verabenzoamine ( 4 ), verazine ( 5 ), isoverazine ( 6 ), and verazinine ( 7 ). Their structures were established by extensive analysis of spectroscopic data, as well as by comparison with literature data. Compounds 1 – 7 could cause DNA damage in the cerebellum and cerebral cortex of mice in a dose‐dependent manner by using single‐cell gel electrophoresis (comet assay). |
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| Keywords: | Veratrum maackii Alkaloids Cyclopamine 3‐O‐β ‐D‐glucopyranoside 23‐methoxy‐ Isoecliptalbine Genotoxicity |
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