Sesquiterpenes from Rhizomes of Cyperus rotundus with Cytotoxic Activities on Human Cancer Cells in vitro |
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| Authors: | Byeol Ryu Hye Mi Kim Jae‐Seung Lee Yoon Jin Cho Myung Sook Oh Jung‐Hye Choi Dae Sik Jang |
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| Affiliation: | 1. Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul 130‐701, South Korea;2. Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Kyungheedae‐ro 26, Dongdaemun‐gu, Seoul 130‐701, South Korea, (phone: +82‐2‐9610719;3. fax: +82‐2‐9663885) |
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| Abstract: | Two new sesquiterpenes, cyperusol A3 ( 1 ) and 3β‐hydroxycyperenoic acid ( 2 ), along with three known sesquiterpenes, britanlin E ( 3 ), 1β,4α‐dihydroxyeudesm‐11‐ene ( 4 ), and 11,12‐dihydroxyeudesm‐4‐en‐3‐one ( 5 ), were isolated from the AcOEt‐soluble fraction of rhizomes of Cyperus rotundus L. The structures of 1 and 2 were elucidated by physical and spectroscopic methods (1H‐ and 13C‐NMR, 2D‐NMR, and MS). All of the isolates, 1 – 5 , were evaluated for their cytotoxic activities against human ovarian cancer cells (A2780) and endometrial adenocarcinoma cells (Ishikawa) using MTT assays. |
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| Keywords: | Cyperus rotundus Cytotoxic activity Guaiane sesquiterpenes Patchoulane sesquiterpenes |
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