Two New Degraded Triterpenoids and a Novel seco‐Norabietane Diterpene from the Root Bark of Azadirachta indica |
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| Authors: | Iffat Dilshad Bina S. Siddiqui Shaheen Faizi |
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| Affiliation: | 1. HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan (phone: +92‐21‐99261716;2. fax: +92‐21‐99261713‐14, +92‐21‐34819018‐19) |
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| Abstract: | Three new compounds, the degraded ring C‐seco‐tetranortriterpenoid nimbolicidin ( 1 ), the degraded hexanortriterpenoid nimbocin ( 2 ), and the seco‐norabietane diterpene nimbocinin ( 3 ), were isolated from the root bark of Azadirachta indica A.Juss . Compound 1 is O‐bearing both at C(28) and C(29), which has been hitherto unreported in tetranortriterpenoids; 2 represents the first hexanortriterpenoid with a truncated apotirucallane (or apoeuphane) skeleton; 3 is an unprecedented seco‐norabietane. Spectroscopic data and chemical transformations of these compounds provided their complete structures. |
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| Keywords: | Tetranortriterpenoids Hexanortriterpenoids Triterpenoids Norabietanes Azadirachta indica |
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