Efficient catalyst for the Suzuki-Miyaura coupling of potassium aryl trifluoroborates with aryl chlorides |
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| Authors: | Barder Timothy E Buchwald Stephen L |
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| Affiliation: | Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. |
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| Abstract: | Palladium-catalyzed Suzuki-Miyaura cross-coupling reactions of aryl- and heteroaryl chlorides with potassium aryl- and heteroaryltrifluoroborates have been accomplished with the supporting ligand S-Phos in good to excellent yield. Hindered biaryls and substrates containing a variety of functional groups can be prepared. Suzuki-Miyaura couplings of a 3-pyridyl boron-based nucleophile with aryl- and heteroaryl chlorides proceed in good to very good yield. [reaction: see text] |
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