Microwave-promoted automated synthesis of a coumarin library |
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Authors: | M. Katkevičs A. Kontijevskis I. Mutule E. Sūna |
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Affiliation: | (1) Latvian Institute of Organic Synthesis, Riga, Latvia |
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Abstract: | A 30-membered library of coumarins has been synthesized in a microwave-assisted Pechmann reaction using neat trifluoroacetic acid both as an acidic reagent and a reaction medium. Alternatively, polymer-supported sulfonic acid Amberlyst-15 could also be employed to facilitate the formation of coumarins. The use of a specially-built microwave synthesizer with liquid handling tools rendered the automated synthesis of a coumarin library feasible. __________ Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 200–208, February, 2007. |
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Keywords: | coumarin microwave promoted synthesis library synthesis |
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