An experimental study of pulsed micro-flows pertinent to continuous subcutaneous insulin infusion therapy |
| |
| Authors: | Bin Wang Ayodeji Demuren Eric Gyuricsko Hui Hu |
| |
| Affiliation: | 1.Aerospace Engineering Department,Iowa State University,Ames,USA;2.Mechanical Engineering Department,Old Dominion University,Norfolk,USA;3.Children’s Hospital of The King’s Daughters,Eastern Virginia Medical School,Norfolk,USA |
| |
| Abstract: | An experimental study was conducted to investigate the unsteady micro-flow driven by an insulin pump commonly used in continuous subcutaneous insulin infusion (CSII) therapy. A microscopic particle image velocimetry (PIV) system was used to characterize the transient behavior of the micro-flow upon the pulsed excitation of the insulin pump in order to elucidate the underlying physics for a better understanding of the microphysical process associated with the insulin delivery in CSII therapy. The effects of air bubbles entrained inside the micro-sized CSII tubing system on the insulin delivery process were also assessed based on the micro-PIV measurements. While most solutions to insulin occlusion-related problems are currently based on clinical trials, the findings derived from the present study can be used to provide a better guidance for the troubleshooting of insulin occlusion in CSII therapy. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
