Chemo-enzymatic synthesis of fluorinated 2-N-acetamidosugar nucleotides using UDP-GlcNAc pyrophosphorylase |
| |
| Authors: | Feng Fei Okuyama Kiyoshi Niikura Kenichi Ohta Takashi Sadamoto Reiko Monde Kenji Noguchi Toshitada Nishimura Shin-Ichiro |
| |
| Institution: | Laboratory for Bio-Macromolecular Chemistry, Division of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo, Japan. |
| |
| Abstract: | Two non-natural fluorinated 2-N-acetamidosugar nucleotides, uridine 5'-diphosphate (UDP) 2-acetamido-2,4-dideoxy-4-fluoro-alpha-D-glucopyranose (UDP-4-FGlcNAc) 1 and its galacto isomer (UDP-4-FGalNAc) 2, were enzymatically constructed by treating chemically synthesized fluorinated 2-N-acetamidosugar 1-phosphates as the donor with UDP 2-acetamido-2-deoxy-alpha-D-glucopyranose pyrophosphorylase in the presence of uridine 5'-triphosphate (UTP). |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
