Bis- and trisuracil nucleosides with nucleobases anchored to 11-, 12-, and 16-membered macrocyclic scaffolds: synthesis and aggregation study |
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Authors: | Sengupta Jhimli Mukhopadhyay Ranjan Bhattacharjya Anup |
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Institution: | Chemistry Department, Indian Institute of Chemical Biology, 4, Raja S. C. Mullick Road, Kolkata 700032, India. |
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Abstract: | Bis- and trisuracil nucleosides, in which the nucleobases are anchored to isoxazoline ring-fused 11-, 12-, and 16-membered macrooxacycles, were synthesized by nucleosidation of 1,2-isopropylidenefuranose ring-fused macrocycles. The nucleosides exhibited spherical and fiber-like morphologies in water. In one case, the morphology was significantly altered by complexation with an adenine nucleoside via complementary base pairing. |
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