Colloidal particle motion as a diagnostic of DNA conformational transitions |
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| Authors: | Philip C Nelson |
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| Institution: | aDepartment of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104 USA |
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| Abstract: | Tethered particle motion is an experimental technique to monitor conformational changes in single molecules of DNA in real time, by observing the position fluctuations of a micrometer-size particle attached to the DNA. This article reviews some recent work on theoretical problems inherent in the interpretation of TPM experiments, both in equilibrium and dynamical aspects. |
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| Keywords: | Tethered motion Hidden Markov DNA conformation DNA looping Single-particle tracking |
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