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DNA Binding and Equilibrium Investigation of the Interaction of a Model Pd(II) Complex with Some Selected Biorelevant Ligands
Authors:Azza A Shoukry
Institution:1. Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Egypt
2. Department of Chemistry, Faculty of Science for Girls, King Abdulaziz University, 50918, Jeddah, 21533, Kingdom of Saudi Arabia
Abstract:The Pd(DAP)Cl2 complex, where DAP is 2,6-diaminopyridine, was synthesized and characterized. The stoichiometries and stability constants of the complexes formed between various biologically relevant ligands (amino acids, amides, DNA constituents, and dicarboxylic acids) and Pd(DAP)(H2O)2]2+ were investigated at 25 °C and at constant 0.1 mol·dm?3 ionic strength. The concentration distribution diagrams of the various species formed were evaluated. A further investigation of the binding properties of the diaqua complex Pd(DAP)(H2O)2]2+ with calf thymus DNA (CT-DNA) was investigated by UV–Vis spectroscopy. The intrinsic binding constants (K b) calculated from UV–Vis absorption studies is 1.04 × 103 mol·dm?3. The calculated (K b) value was found to be of lower magnitude than that of the classical intercalator EB (ethidium bromide) (K b = 1.23 (±0.07) × 105 mol·dm?3), suggesting an electrostatic and/or groove binding mode for the interaction with CT-DNA.
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