Approach to the hyacinthacines: first non-chiral pool synthesis of (+)-hyacinthacine A1 |
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| Authors: | Reddy P Venkatram Veyron Amaël Koos Peter Bayle Alexandre Greene Andrew E Delair Philippe |
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| Institution: | Département de Chimie Moléculaire (SERCO) UMR-5250, ICMG FR-2607, CNRS Université Joseph Fourier, BP-53, 38041, Grenoble Cedex 9, France. |
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| Abstract: | The first non-chiral pool total synthesis of (+)-hyacinthacine A(1) is described. This synthesis is based on an effective 2 + 2] cycloaddition of dichloroketene to a Stericol-based enol ether, a diastereoselective dihydroxylation, and an efficient Tamao-Fleming oxidation. |
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