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Dysidavarones A-D, new sesquiterpene quinones from the marine sponge Dysidea avara
Authors:Jiao Wei-Hua  Huang Xiao-Jun  Yang Ji-Si  Yang Fan  Piao Shu-Jian  Gao Hao  Li Jia  Ye Wen-Cai  Yao Xin-Sheng  Chen Wan-Sheng  Lin Hou-Wen
Institution:Laboratory of Marine Drugs, Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, PR China.
Abstract:Dysidavarones A-D (1-4), four new sesquiterpene quinones possessing the unprecedented "dysidavarane" carbon skeleton, were isolated from the South China Sea sponge Dysidea avara. The structures were established by spectroscopic methods, and the absolute configurations were determined using quantum mechanical calculation of the electronic circular dichroic (ECD) spectrum and exciton chirality CD method. Their cytotoxic activity against four human cancer cell lines and PTP1B inhibitory activity were also evaluated.
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