Additive-free nucleophilic addition of imidazolines and imidazoles to haloacetylenes |
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| Authors: | Yamagishi Masahito Okazaki Jun Nishigai Ken Hata Takeshi Urabe Hirokazu |
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| Institution: | Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Kanagawa 226-8501, Japan. |
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| Abstract: | Nucleophilic addition of imidazolines to 1-halo-1-alkynes takes place by simple heating in DMF without any additives to give (Z)-N-(1-halo-1-alken-2-yl)imidazolines in good yield and in a highly regio- and stereoselective manner. These reaction conditions are also valid for the similar addition of imidazoles. |
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