PdCl2-catalyzed heterocyclotrimerization in MeOH/scCO2: A versatile approach to dimethyl pyridine-3,5-dicarboxylate from methyl acrylate and urea |
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| Authors: | Bo Zou and HuanFeng Jiang |
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| Affiliation: | (1) College of Chemistry, South China University of Technology, Guangzhou, 510640, China |
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| Abstract: | A novel and green method for the synthesis of dimethyl pyridine-3,5-dicarboxylate has been developed. It is PdCl2-catalyzed heterocyclotrimerization of methyl acrylate with urea in methanol/supercritical carbon dioxide. The target compound was obtained with a 75% isolated yield under the optimized conditions. Supported by the National Natural Science Foundation of China (Grant Nos. 20332030, 20572027, 20625205 and 20772034) and Guangdong Natural Science Foundation (Grant No. 07118070) |
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| Keywords: | PdCl2 heterocyclotrimerization dimethyl pyridine-3,5-dicarboxylate scCO2 |
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