A highly automated, polymer-assisted strategy for the preparation of 2-alkylthiobenzimidazoles and N,N'-dialkylbenzimidazolin-2-ones |
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Authors: | Vickerstaffe Emma Warrington Brian H Ladlow Mark Ley Steven V |
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Institution: | GlaxoSmithKline Cambridge Technology Centre, University Chemical Laboratory, Lensfield Road, Cambridge, CB2 1EW, United Kingdom. |
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Abstract: | A multistep, polymer-assisted solution phase strategy for the highly automated (auto-PASP) synthesis of 2-alkylthiobenzimidazole and N,N'-dialkylbenzimidazolin-2-one libraries is presented. The approach incorporates in-line purification techniques to afford library products directly with high purities and is exemplified by the preparation of a 96-member 2-alkylthiobenzimidazoline library 11-12,1-8] and a 72-member N,N'-dialkylbenzimidazolin-2-one library 91-12,1-6]. |
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