| Synthesis of Fluoroalkylated Heterocycles via the Reaction of 3-(1-Hydropolyfluoroalkenyl)-1-oxo-2,4,1-benzoxazines with Dinucleophilic Reagents |
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| 作者姓名： | 杨先金 刘金涛 |
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| 作者单位： | College of Chemistry and Molecular Engineering East China University of Science and Technology，Shanghai 200237，China，Shanghai Institute of Organic Chemistry，Chinese Academy of Sciences，Shanghai 200032，China |
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| 基金项目： | Project supported by the National Natural Science Foundation of China(No.20172065). |
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| 摘 要： | The reaction of 3-(1-hydropolyfluoroalkenyl)-1-oxo-2,4,1-benzoxazines 1 with some dinucleophiles was inves-tigated.7-Fluoroalkyl-2,3-dihydro-1,4-diazepine1,2-d]quinazolin-11-ones 2,2-fluoroalkylisoxazolo3,2-b]quin-azolin-9-ones 3 and 2-fluoroalkylbenzoimidazoles 4 were obtained from the reaction of 1 with 1,2-diaminoethane,hydroxylamine hydrochloride and 1,2-diaminobenzene respectively.
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Synthesis of Fluoroalkylated Heterocycles via the Reaction of 3-(1-Hydropolyfluoroalkenyl)-1-oxo-2,4,1-benzoxazines with Dinucleophilic Reagents |
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| YANG Xian-Jina LIU Jin-Tao
a College of Chemistry and Molecular Engineering,East China University of Science and Technology,Shanghai ,China
b.Synthesis of Fluoroalkylated Heterocycles via the Reaction of 3-(1-Hydropolyfluoroalkenyl)-1-oxo-2,4,1-benzoxazines with Dinucleophilic Reagents[J].Chinese Journal of Chemistry,2006(10). |
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| Authors: | YANG Xian-Jina LIU Jin-Tao
a College of Chemistry and Molecular Engineering East China University of Science and Technology Shanghai China
b |
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| Institution: | YANG Xian-Jin~a LIU Jin-Tao~*
a College of Chemistry and Molecular Engineering,East China University of Science and Technology,Shanghai 200237,China
b Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China |
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| Abstract: | The reaction of 3-(1-hydropolyfluoroalkenyl)-1-oxo-2,4,1-benzoxazines 1 with some dinucleophiles was inves- tigated.7-Fluoroalkyl-2,3-dihydro-1,4-diazepine1,2-d]quinazolin-11-ones 2,2-fluoroalkylisoxazolo3,2-b]quin- azolin-9-ones 3 and 2-fluoroalkylbenzoimidazoles 4 were obtained from the reaction of 1 with 1,2-diaminoethane, hydroxylamine hydrochloride and 1,2-diaminobenzene respectively. |
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| Keywords: | fluoroalkylated heterocycle dinucleophile synthesis |
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