An improved large scale procedure for the preparation of N-Cbz amino acids |
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Authors: | Ashok D PehereAndrew D Abell |
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Institution: | School of Chemistry & Physics, The University of Adelaide, North Terrace, Adelaide SA 5005, Australia |
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Abstract: | A simple and scalable method for the preparation of N-Cbz protected amino acids is presented which uses a mixture of aqueous sodium carbonate and sodium bicarbonate to maintain the appropriate pH during the addition of benzyl chloroformate. The method has been extended to other N-protections and is amenable to large scale preparation of an intermediate toward Zofenopril, an ACE inhibitor. |
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Keywords: | N-Cbz amino acids Synthesis Large scale Zofenopril |
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