Anabasine and cytisine derivatives as reversible cholinesterase inhibitors

A number of analogs of acetyl--methylcholine, containing residues of the alkaloids anabasine and cytisine as cyclic ammonium groupings, have been synthesized. The structures of the substances obtained have been confirmed by their IR and PMR spectra and the result of elementary analysis. The kientic parameters of the interaction of the compounds synthesized with acetylcholinesterase (ACE) of human blood erythrocytes and with butylcholinesterase (BuCE) of horse blood serum have been investigated. All the substances synthesized proved to be reversible inhibitors of ACE and BuCE.Institute of Bioorganic Chemistry, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 97–100, January–February, 1988.