| Site-specifically cleavage of oxidized insulin B chain with Zn（Ⅱ） ion studied by electrospray ionization mass spectrometry |
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| 引用本文： | Jiang Jiang Yu Hua Mei Long Gen Zhu Wen Ji Wang. Site-specifically cleavage of oxidized insulin B chain with Zn（Ⅱ） ion studied by electrospray ionization mass spectrometry[J]. 中国化学快报, 2007, 18(5): 557-560. DOI: 10.1016/j.cclet.2007.03.016 |
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| 作者姓名： | Jiang Jiang Yu Hua Mei Long Gen Zhu Wen Ji Wang |
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| 作者单位： | [1]College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002, Chin [2]College of Life Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China [3]State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, China |
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| 摘 要： | The electrospray ionization mass spectrometry and tandem mass spectrometry investigation showed that the binding sites of Zn^2＋ with oxidized insulin B chain are His 5, His 10, and Arg 22, which lead to the selective cleavages of the peptide bonds at Ash 3- Gin 4, His 5-Leu 6, Gly 8-Ser 9, and Glu 21-Arg 22 of oxidized insulin B chain.
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| 关 键 词： | 氧化胰岛素 B链 Zn（Ⅱ）离子 位点特异性分裂 电喷雾离子化质谱法 |
| 收稿时间： | 2006-11-13 |
Site-specifically cleavage of oxidized insulin B chain with Zn(II) ion studied by electrospray ionization mass spectrometry |
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| Jiang Jiang,Yu Hua Mei,Long Gen Zhu,Wen Ji Wang,. Site-specifically cleavage of oxidized insulin B chain with Zn(II) ion studied by electrospray ionization mass spectrometry[J]. Chinese Chemical Letters, 2007, 18(5): 557-560. DOI: 10.1016/j.cclet.2007.03.016 |
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| Authors: | Jiang Jiang Yu Hua Mei Long Gen Zhu Wen Ji Wang |
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| Affiliation: | 1. College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002, China;2. College of Life Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China;3. State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, China |
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| Abstract: | The electrospray ionization mass spectrometry and tandem mass spectrometry investigation showed that the binding sites of Zn2 with oxidized insulin B chain are His 5, His 10, and Arg 22, which lead to the selective cleavages of the peptide bonds at Asn 3-Gln 4, His 5-Leu 6, Gly 8-Ser 9, and Glu 21-Arg 22 of oxidized insulin B chain. |
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| Keywords: | Oxidized insulin B chain ZnCl2 Mass spectrometry Hydrolytic cleavage |
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