Ca/Zn-纳米羧甲基壳聚糖的光谱分析

以壳聚糖为原料,经羧甲基化、纳米化与Ca~(2+)、Zn~(2+)复合制备出纳米羧甲基壳聚糖含钙、锌复合物,采用红外光谱、X射线衍射光谱、扫描电镜等光学手段对样品进行结构表征,考察了复合物的凝血、止血性能。结果表明:纳米羧甲基壳聚糖结构中含有磷酸盐结构,Ca/Zn-纳米羧甲基壳聚糖结构中含有Ca~(2+)与Zn~(2+),Ca~(2+)和Zn~(2+)与纳米羧甲基壳聚糖成功复合;复合物的结晶性下降、溶解性提高、形貌均匀圆整,且凝血、止血时间明显缩短;Ca-纳米羧甲基壳聚糖比Zn-纳米羧甲基壳聚糖结构更稳定,凝血、止血效果更好。

Spectral Analysis of Ca/Zn-nano Carboxymethyl Chitosan

With chitosan as raw material, Ca/Zn-nano carboxymethyl chitosan complexing was pre-pared through carboxymethylation, nanocrystallization and complexing with Ca2+, Zn2+. The struc-ture was characterized by infrared spectroscopy, X-ray diffraction spectroscopy and scanning electron microscopy. The properties of coagulation and hemostatic were investigated. The results show that the polyphosphate structure is contained in nano carboxymethyl chitosan, as Ca2+ and Zn2+ are con-tained in Ca/Zn-nano carboxymethyl chitosan. Ca2+ and Zn2+ compound successfully with nano car-boxymethyl chitosan. The composite has lower crystallization, higher solubility, more uniform round morphology and significant shorter coagulation and hemostasis time. Compared with Zn-nano car-boxymethyl chitosan, Ca-nano carboxymethyl chitosan is possessed better structure and better prop-erties of coagulation and hemostasis.