Stereoselective synthesis of 2-substituted 6-[1-(2,6-difluorophenyl)ethyl]-5-methylpyrimidin-4(3<Emphasis Type="Italic">H</Emphasis>)-ones |
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| Authors: | A Mai M Artico D Rotili I A Novakov B S Orlinson M B Navrotskii A S Eremiichuk E A Gordeeva |
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| Institution: | (1) Pharmaceutical Chemistry Division, Department of Pharmaceutical Sciences, Dr. H.S. Gour University, Sagar, India;(2) Preclinical Pharmacology Section, Epilepsy Branch, National Institutes of Health, Bethesda, MD 20892-9020, USA |
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| Abstract: | A procedure has been proposed for the synthesis of 2-(cyclopentylsulfanyl)-6-(1R)-1-(2,6-difluorophenyl) ethyl]-5-methylpyrimidin-4(3H)-one through intermediate (3R)-4,4-dimethyl-2-oxotetrahydrofuran-3-yl (2R)-2-(2,6-difluorophenyl)propanoate which was obtained from prochiral 2-(2,6-difluorophenyl)prop-1-en-1-one generated in situ. The proposed procedure may be regarded as stereoselective route to 6-(1R)-1-(2,6- difluorophenyl)ethyl]-5-methylpyrimidin-4(3H)-one derivatives. |
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