Phosphorylimidazole derivatives: potentially biosignaling molecules |
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Authors: | Orth Elisa S Wanderlind Eduardo H Medeiros Michelle Oliveira Pedro S M Vaz Boniek G Eberlin Marcos N Kirby Anthony J Nome Faruk |
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Affiliation: | INCT-Catalise, Universidade Federal de Santa Catarina, Floriano?polis, SC 88040-900, Brazil. |
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Abstract: | The phosphorylation of imidazole by two activated phosphate diesters and a triester gives phosphorylimidazole derivatives that are stable enough in aqueous solution to be observed and identified by ESI-MS/MS and NMR. Half-lives ranging from hours to days (in the case of the monoethyl ester) show that it is possible to design molecules with variable half-lives with potential to be used for biological intervention experiments as possible inhibitors of biosignaling processes or as haptens for the generation of antibodies. |
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