Inclusion Compounds of Nitrosobenzenes with Cholic Acid and Deoxycholic Acid |
| |
Authors: | Maria Gdaniec Tomasz Bytner Monika Szyrszyng Tadeusz Połonski |
| |
Affiliation: | (1) Faculty Of Chemistry, A, Mickiewicz University, 60-780 Pozna, Poland;(2) Department of Chemistry, Technical University, 80-952 Gdask, Poland |
| |
Abstract: | The crystalline inclusion compounds of cholic acid (CA) and deoxycholic acid (DCA) with several nitrosobenzenes were prepared. The IR spectra and crystal structures of these compounds confirmed inclusion of the monomeric form of the C-nitroso compounds. The DCA compounds have 2 : 1 host:guest stoichiometry and P21 symmetry. Guest molecules are enclosed in channels and disordered. In the CA-nitrobenzene inclusion compound (1·CA) the host:guest stoichiometry is 1 : 1. The host molecules form typical CA bilayer aggregates and guest molecules are accommodated in helicoidal channels. The guest nitroso group is not coplanar with the phenyl ring; the torsion angle on the C–N bond is 8.6(8)°. The solid-state circular dichroism spectrum of 1·CA shows the negative Cotton effect at 780 nm corresponding to the n–* electronic transition that can be associated with the P helicity of the guest molecule. The extremely weak magnitude of the Cotton effects exhibited by the DCA complexes points to a nearly planar arrangement of the NO group and the phenyl ring in the guest molecules. |
| |
Keywords: | bile acids cholic acid circular dichroism deoxycholic acid nitrosobenzenes X-ray crystallography |
本文献已被 SpringerLink 等数据库收录! |