| 人肌无力症骨骼肌纤维的超微病理改变 |
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| 引用本文： | 刘贵生,李双庆,薛平,马洪骏,雷建章.人肌无力症骨骼肌纤维的超微病理改变[J].电子显微学报,2006,25(1):45-47. |
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| 作者姓名： | 刘贵生 李双庆 薛平 马洪骏 雷建章 |
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| 作者单位： | 1. 河北医科大学电镜实验中心,河北,石家庄,050017
2. 武警8645部队医院,河北,石家庄,050000 |
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| 摘 要： | 为研究肌无力症患者骨骼肌纤维的超微病理变化，采用超薄切片透射电镜观察分析法。电镜下可见到肌纤维局部肌节变形、粗细肌丝紊乱、明暗带不清、Z盘模糊、三联体减少、线粒体残损空泡化、糖原颗粒沉积、脂褐素增多以及肌纤维间质液化。骨骼肌原纤维及细胞器超微结构改变时肌无力超微病理诊断有重要意义。
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| 关 键 词： | 肌无力症 骨骼肌纤维 肌细胞器 超微病理 |
| 文章编号： | 1000-6281（2006）01-0045-03 |
| 收稿时间： | 2005-05-19 |
| 修稿时间： | 2005-05-192005-09-01 |
Ultrapathological changes of skeletal myofiber in human amyosthenia |
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| LIU Gui-sheng,LI Shuang-qing,XUE Ping,MA Hong-jun,LEI Jian-zhang.Ultrapathological changes of skeletal myofiber in human amyosthenia[J].Journal of Chinese Electron Microscopy Society,2006,25(1):45-47. |
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| Authors: | LIU Gui-sheng LI Shuang-qing XUE Ping MA Hong-jun LEI Jian-zhang |
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| Institution: | 1 Dept of Electron Microscopy, Hebei Medical University, Shijiazhuang Heibei 050017 ; 2 Army Hospital of arming policeman, Shijiazhuang Hebei 050000, China |
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| Abstract: | To study the ultrapothological changes of skeletal myofibril in human myoasthenia.Ultrathin sections of peroneal muscle from 20 cases of amyosthenia were observed under the transmission electron microscope.Some areas of the peroneal muscle fiber showed the changes as follows: 1)Deformation of sarcomere;2)Disordered and intersected thin and thick myofilaments;3)Undiscernible I and A band;4)Blurred Z disc;5)Decrease in number of the triad of muscle fibers;6)Vacuolation and lamellar structure formation in the mitochondria;7)Abnormal deposition glycogen granules;8)Increase in number and size of lipofuscin granules;9)Liquefaction of the intercellular substance,etc.The ultrastructural changes of skeletal muscle myofibril possess an important significance for the pathological diagnosis of human myoasthenia. |
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| Keywords: | myoasthenia skeletal muscle fiber muscle cell organelle ultrapathology |
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