Effect of electroelastic anisotropy of DNA-like molecules on their tertiary structure |
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Authors: | V L Golo Yu M Evdokimov E I Kats |
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Institution: | (1) Mechanico-Mathematical Department of M. V. Lomonosov Moscow State University, 119899 Moscow, Russia;(2) Institute of Molecular Biology, Russian Academy of Sciences, 117984 Moscow, Russia;(3) L. D. Landau Institute of Theoretical Physics, Russian Academy of Sciences, 117940 Moscow, Russia |
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Abstract: | Under certain conditions, mechanical forces can cause an anisotropic molecule like DNA to assume a toroidal spatial structure.
A simple model describing such a behavior is suggested. The model incorporates anisotropic elastic energy and external electrical
forces. The steady-state structures formed by a macromolecule have been studied numerically using this model. There exist
ranges of model parameters, namely, the anisotropy of the elastic tensor, magnitude and orientation of forces, and modulation
periods, where molecules have toroidal, spherical, or extended structures. Estimates of parameters characteristic of these
structures are consistent with experimental data. In particular, the toroidal structure dimension corresponds to experimental
dimensions of toroidal globules produced as a result of so-called PSI condensation of DNA molecules.
Zh. éksp. Teor. Fiz. 112, 2156–2168 (December 1997) |
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