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Tailored Poly(2‐oxazoline) Polymer Brushes to Control Protein Adsorption and Cell Adhesion |
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| Authors: | Ning Zhang Tilo Pompe Ihsan Amin Robert Luxenhofer Carsten Werner Rainer Jordan |
| Institution: | 1. Wacker‐Lehrstuhl für Makromolekulare Chemie, Chemie‐Department, TU München, Lichtenbergstr. 4, 85748 Garching, Germany;2. Max Bergmann Center of Biomaterials, Leibniz Institute of Polymer Research Dresden, 01069 Dresden, Germany;3. Current Address: Institute of Biochemistry, Universit?t Leipzig, Johannisallee 21, 04103 Leipzig, Germany;4. Lehrstuhl für Makromolekulare Chemie, Chemie‐Department, TU Dresden, Zellescher Weg 19, 01069 Dresden, Germany;5. Center for Regenerative Therapies Dresden, Dresden, Germany |
| Abstract: | POx bottle‐brush brushes (BBBs) are synthesized by SIPGP of 2‐isopropenyl‐2‐oxazoline and consecutive LCROP of 2‐oxazolines on 3‐aminopropyltrimethoxysilane‐modified silicon substrates. The side chain hydrophilicity and polarity are varied. The impact of the chemical composition and architecture of the BBB upon protein (fibronectin) adsorption and endothelial cell adhesion are investigated and prove extremely low protein adsorption and cell adhesion on BBBs with hydrophilic side chains such as poly(2‐methyl‐2‐oxazoline) and poly(2‐ethyl‐2‐oxazoline). The influence of the POx side chain terminal function upon adsorption and adhesion is minor but the side chain length has a significant effect on bioadsorption.  |
| Keywords: | cell adhesion polymer brushes polyoxazolines protein adsorption surface‐initiated polymerization |