Structure determination of two new trichothecenes from a halotolerant fungus Myrothecium sp. GS‐17 by NMR spectroscopy |
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| Authors: | Song‐Ya Zhang Zhan‐Lin Li Li‐Ping Guan Xin Wu Hua‐Qi Pan Jiao Bai Hui‐Ming Hua |
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| Affiliation: | 1. Key Laboratory of Structure‐Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, , Shenyang, 110016 China;2. Department of Natural Product Chemistry, Shenyang Pharmaceutical University, , Shenyang, 110016 China;3. School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, , Shenyang, 110016 China;4. Institute of Applied Ecology, Chinese Academy of Sciences, , Shenyang, 110016 China |
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| Abstract: | Two new trichothecenes, named 8α‐hydroxyroridin H and myrothecin A, along with six known compounds, 8α‐acetoxy roridin H, isororidin K, verrucarin A, verrucarin J, verrucarin L and 8α‐acetoxy verrucarin L, were isolated from the fermentation broth of a halotolerant fungus Myrothecium sp. GS‐17, which was separated from the soil sample of a salina. Structure elucidation and NMR signal assignments were achieved on the basis of spectroscopy. In addition, compounds 1 and 2 were active against plant pathogenic fungi Rhizoctonia solani and Fusarium oxysporum. Copyright © 2012 John Wiley & Sons, Ltd. |
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| Keywords: | NMR 1H NMR 13C NMR trichothecenes Myrothecium sp antifungal activity |
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