Physicochemical characterization and drug release properties of PDMAEMA/OSA Semi‐IPN hydrogels with microporous structure |
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| Authors: | Chunmei Gao Mingzhu Liu Jun Chen Chen Chen |
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| Institution: | Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China |
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| Abstract: | A new poly(2‐(dimethylamino) ethyl methacrylate)/oxidized sodium alginate (PDMAEMA) semi‐interpenetrating network (Semi‐IPN) hydrogel with microporous structure was prepared by using PDMAEMA microgels as an additive during the polymerization/crosslinking process. The interior morphology characterized by scanning electron microscopy showed the Semi‐IPN hydrogels have different pore sizes by changing the amount of microgels. The hydrogels were also characterized by using Fourier transform infrared and DSC. The swelling behaviors of hydrogels indicated that the hydrogels have excellent pH and temperature sensitivity. Bovine serum albumin was entrapped in the hydrogels and the in vitro drug release profiles were established in different buffer solutions at various temperatures. The release behaviors of the model drug were dependent on the pore size of the hydrogels and environmental temperature/pH, which suggested that these materials have potential application as intelligent drug carriers. Copyright © 2011 John Wiley & Sons, Ltd. |
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| Keywords: | poly(2‐(dimethylamino) ethyl methacrylate) semi‐interpenetrating hydrogel microporous structure drug release |
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