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Design of a Cellular‐Uptake‐Shielding Magnetic Catcher for Cancer Cell Separation
Authors:Hui‐Zhen Jia  Juan Yang  Si‐Yong Qin  Chen‐Wei Liu  Ren‐Xi Zhuo  Xian‐Zheng Zhang
Affiliation:Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, China
Abstract:Fluorescent‐magnetic‐biotargeting multifunctional microcapsules (FMBMMs) are designed and fabricated via layer‐by‐layer assembly. It is found that the arginine‐glycine‐aspartate‐modified FMBMMs were capable of sensitively detecting and efficiently isolating approximately 80% target cancer cells within 20 min. More importantly, FMBMMs present a general template for identifying and separating multiple types of cancer cells simply by altering the recognition motif.
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Keywords:cancer cells  layer‐by‐layer assembly  magnetic nanoparticles  multifunctional microcapsules  RGD
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