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Glycogen as a Biodegradable Construction Nanomaterial for in vivo Use |
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| Authors: | Sergey K. Filippov Ondrej Sedlacek Anna Bogomolova Miroslav Vetrik Daniel Jirak Jan Kovar Jan Kucka Sara Bals Stuart Turner Petr Stepanek Martin Hruby |
| Affiliation: | 1. Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, v. v. i., Heyrovsky Sq. 2, 162 06 Prague 6, Czech Republic;2. Institute of Clinical and Experimental Medicine, 1958/9, 140 21 Prague 4, Czech Republic;3. EMAT, University of Antwerp, B‐2020 Antwerp, Belgium |
| Abstract: | It is demonstrated that glycogen as a biodegradable and inexpensive material coming from renewable resources can be used as a carrier for the construction of in vivo imaging nanoagents. The model system considered is composed of glycogen modified with gadolinium and fluorescent labels. Systematic studies of properties of these nanocarriers by a variety of physical methods and results of in vivo tests of biodegradability are reported. This represents, to the authors' best knowledge, the first such use of glycogen.  |
| Keywords: | biodegradable glycogen in vivo imaging nanoparticles |