1. Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China;2. Key Laboratory of Functional Polymer Materials, Ministry of Education, Department of Chemistry, Nankai University, Tianjin 300071, China
Abstract:
Comb‐shaped glycopolymer/peptide bioconjugates are constructed by grafting reduced glutathione (GSH) onto acrylate‐functional block glycocopolymers via thiol‐ene click chemistry. In aqueous solution, the glycopolymer/GSH bioconjugate self‐assembles to sugar‐installed spherical micelles. The size of micelles decreases with increasing pH, demonstrating pH‐responsive character. The isoelectric point (IEP) of the PMAGlc/GSH bioconjugate is estimated to be 3.43. The micelles show a specific interaction with the protein Concanavalin A. At endosomal pH, the PMAGlc/GSH bioconjugate can gradually degrade. These pH‐responsive glycopolymer/peptide micelles with biological recognition and degradation can be used as multifunctional nanocarriers for targeted drug delivery.
