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Characterization of an unusual ring‐contraction degradant of the antifungal agent posaconazole |
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| Authors: | Wenqing Feng Bruce D Hilton Wendy Zhong Jiong Yang Xi Yang Weidong Tong Gary E Martin |
| Institution: | 1. Merck Research Laboratories, Discovery and Preclinical Sciences, Process Chemistry – Structure Elucidation Group, , Summit, NJ, USA;2. Global Science and Technology Center, Merck Manufacturing Division, , Summit, NJ, USA;3. Merck Research Laboratories, Discovery and Preclinical Sciences, Process Chemistry, , Rahway, NJ, USA |
| Abstract: | Posaconazole, a clinically useful antifungal agent, has several known oxidative degradation products involving the piperazine ring near the center of the molecule. A novel degradant was recently isolated and characterized spectroscopically as a novel ring‐contraction product incorporating a dihydroimidazolium moiety in lieu of the normally present piperazine ring. Copyright © 2012 John Wiley & Sons, Ltd. |
| Keywords: | posaconazole antifungal degradation product 1H‐13C GHMBC 1‵ H‐15N GHMBC ROESY |