Synthesis and structure elucidation of five new conjugates of oleanolic acid derivatives and chalcones using 1D and 2D NMR spectroscopy |
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| Authors: | Chu Tang Linhui Zhu Jun Li Rui Qin Chang Liu Yu Chen Guangzhong Yang |
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| Institution: | 1. Laboratory for Natural Product Chemistry, College of Pharmacy, South Central University for Nationalities, , Wuhan, 430074 China;2. College of Life Sciences, South Central University for Nationalities, , Wuhan, 430074 China;3. College of Chemistry and Material Sciences, South Central University for Nationalities, , Wuhan, 430074 China |
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| Abstract: | Five new conjugates of oleanolic acid derivatives and chalcones have been designed and synthesized. The structure elucidation of these conjugates was accomplished by using extensive 1D (1H, 13C) and 2D NMR spectroscopic studies (COSY, HSQC and HMBC); and α‐glucosidase inhibitory activity is reported for these conjugates. Compound 2b (IC50 = 47.5 µm ) displayed much stronger activity than oleanolic acid and acarbose. Copyright © 2012 John Wiley & Sons, Ltd. |
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| Keywords: | 1H NMR 13C NMR COSY HSQC HMBC structure elucidation oleanolic acid derivative– chalcone conjugates |
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