1. Department of Pharmaceutics and Biopharmacy, Philipps‐Universit?t Marburg, Ketzerbach 63, 35037 Marburg, Germany;2. Novartis Pharma AG, Novartis Campus, 4056 Basel, Switzerland
Abstract:
The aim of this study is to investigate the feasibility and efficacy of PEC nanoparticles as delivery system for cancer chemotherapy. Assembly of paclitaxel‐loaded nanoparticles with high loading efficiency and narrow‐size distribution is successful. For non‐invasive in vivo tracing, nanoparticle blends of chelator bearing poly(lactide) with PEC and PLGA are successfully prepared. Pharmacokinetic studies in mice reveal a twofold higher circulation time of PEC as compared to PLGA. A tumor model shows an accumulation of PEC NPs in cancerous tissue and a higher anti‐tumor efficiency compared to the standard Taxol?, which is reflected in a significantly slower tumor growth compared to the NaCl control group.
