Synthesis and characterization of amphiphilic antibacterial copolymers |
| |
| Authors: | Yong Xiao Bai Yao Bin Liu Yan Feng Li Qi Zhang |
| |
| Institution: | 1. Institute of Material Science and Engineering, Key Laboratory for Magnetism and Magnetic Materials of the Ministry of Education, Lanzhou University, Lanzhou 730000, China;2. Department of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China;3. School of Life Science, Lanzhou University, Lanzhou 730000, China |
| |
| Abstract: | Macromolecule antimicrobials have been explored in foundational research and practical application due to their potential merit for reducing the residual toxicity, increasing their efficiency, selectivity, and prolonging the lifetime of the antimicrobial material. In this work, the quaternized poly(styrene)‐b‐poly(DMAEMA) diblock polymers are synthesized by reversible addition‐fragmentation chain transfer polymerization (RAFT). The minimum inhibitory concentration (MIC) evaluation and optical density (OD) method demonstrated that the amphiphilic antibacterial biomaterials have exceptional antibacterial properties. The amphiphilic polycation has an admirable antibacterial property, and these quaternized diblocks are potent biocides and nonhemolytic. The relationship between the structure and activity is discussed with respect to molecular weight of the diblocks and bacteria structural dependence. Copyright © 2011 John Wiley & Sons, Ltd. |
| |
| Keywords: | biological application biomaterial biopolymer diblock copolymer functional polymer |
|
|
