The structure of glibenclamide in the solid state |
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| Authors: | Dionisia Sanz Rosa M Claramunt Ibon Alkorta Goar Sánchez‐Sanz José Elguero |
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| Institution: | 1. Departamento de Química Orgánica y Bio‐Orgánica, Facultad de Ciencias, Universidad Nacional de Educación a Distancia (UNED), , Madrid, Spain;2. Instituto de Química Médica, CSIC, , Madrid, Spain |
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| Abstract: | The structure of glibenclamide, 5‐chloro‐N‐(2‐{4‐(cyclohexylamino)carbonyl] aminosulfonyl}phenyl) ethyl)‐2‐methoxybenzamide, an important antidiabetic drug, has been studied both in solution and in the solid state by a combination of NMR spectroscopy and theoretical calculations. The possibility that glibenclamide suffers a tautomerization under melting to afford a desmotrope was rejected. Copyright © 2012 John Wiley & Sons, Ltd. |
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| Keywords: | SSNMR GIAO B3LYP/6‐311++G(d p) |
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